Girihlet works on profiling the T cell receptor repertoire accurately to develop an understanding of the immune system. An accurate view of the repertoire is a window into the immune system and the health of an individual. Diagnostic and therapeutic applications can be derived from this technology. Our novel method of profiling the TCR repertoire, and related methods of analyses, form the bases of our work on TCR repertoires.
We have also developed a proprietary method of sequencing mitochondrial DNA which is being used to develop accurate profiles of heteroplasmy. We are using the data to determine clinical significance of mtDNA variants and develop relevant biomarkers.
Our work relies on accumulating data from diverse "normal" humans, which will guide the identification of clinically relevant biomarkers.